Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment

Investigation of the Risk Factors for Congenital Hypothyroidism in Iran: A Population-Based Case-Control Study

Background Congenital hypothyroidism (CH) is one of the most common causes of mental disability, which can be prevented in the case of early diagnosis and treatment. We aimed to study the some relevant risk factors for CH in neonates born in Khorasan Razavi Province, Iran. Materials and Methods: This was a population-based case-control study conducted on 97,380 neonates.The study population c...

Neuro-developmental deficits in early-treated congenital hypothyroidism.

This paper summarises the current evidence on neuro-developmental deficits in the early (< 1 month of age) treated congenital hypothyroid and the influencing factors. A literature search revealed only few citations that compared outcome with matched controls. In all but one, the median age of treatment onset was >2 weeks. Mean Global IQ scores are about 10 points lower and remain identifiable i...

Early detection of congenital hypothyroidism

Congenital hypothyroidism, with an estimated incidence of 1 in 5-10 000 births, is probably the commonest endocrine disorder of early childhood. Its importance lies in the devastating effect which it can have on brain development, leading to subnormality and other manifestations such as clumsiness and hyperactivity. It is common experience that the condition is difficult or impossible to recogn...

[Early detection of congenital hypothyroidism].

Congenital hypothyroidism: a review of the risk factors.

This study was aimed to evaluate the situation of congenital hypothyroidism (CH) in Guilan using the screening program and determine the correlation of CH with birth weight, gestational age and seasonality. During 2006 to 2010, in Guilan province, neonatal screening for CH by measurement of serum TSH level was performed in 3-5 days after birth. All neonates with TSH level ≥ 5mu/l were referred ...